I planned and built a figure-of-eight with gradients, a two-platform station, a single-ended siding and a (working) 4-gate level crossing, as an experimental layout with which to learn techniques before attempting something substantial.
With this layout the fundamental advantage of using dual (+ve & -ve) power supplies had not occured to me. So in order to reverse a loco without using a relay I used H-bridge throttles, without one rail being tied to 0V ("Common Ground/Rail"), and requiring a two-pole relay cab/district matrix. I only went as far as 3 cabs and 4 districts so this was not too bad, and it did allow me to gain a lot of experience with the wider control system.